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Comptes Rendus Physique
Volume 6, n° 4-5
pages 575-581 (mai-juin 2005)
Doi : 10.1016/j.crhy.2005.03.002
Received : 21 February 2005 ;  accepted : 10 Mars 2005
Conversion of a proton pair para order into 13C polarization by rf irradiation, for use in MRI
Conversion de lʼordre para dʼune paire de protons en polarisation de 13C par irradiation rf, pour utilisation en IRM
 

Maurice Goldman a, , 1 , Haukur Jóhannesson b
a 6, résidence de Villebon, 91191 Villebon-sur-Yvette, France 
b GE Healthcare Bio-Sciences, Medeon, 20512 Malmö, Sweden 

Corresponding author.
Résumé

Nous décrivons la théorie de la production de carbone 13 hyper polarisé dans des petites molécules organiques marquées, pour utilisation comme agents de contraste moléculaires en IRM, par un processus en deux grandes étapes. La première est une hydrogénation catalytique avec de lʼhydrogène para dans un petit champ magnétique statique sous irradition de radiofréquence, dont lʼeffet est de produire une paire de protons moléculaires dans un pur état para. La seconde étape convertit cet ordre para en hyperpolarisation globale dʼun carbone 13 voisin par une séquence dʼimpulsions de radiofréquence aux fréquences de résonance des deux espèces de spins. La polarisation théorique finale est proche de lʼunité. Le processus, mis en œuvre avec succès, ne dure que quelques secondes. Pour citer cet article : M. Goldman, H. Jóhannesson, C. R. Physique 6 (2005).

The full text of this article is available in PDF format.
Abstract

We describe the theory of production of hyperpolarized 13C in small organic molecules, for use as molecular contrast agents in MRI, by a two-step process. The first is a catalyzed hydrogenation with para-hydrogen in a small dc magnetic field under rf irradiation, resulting in a molecular proton pair in the pure para state. The second step converts this para order into net hyperpolarization of a nearby carbon 13 through a sequence of rf pulses at the resonance frequencies of both spin species. The final theoretical polarization is close to unity. The whole process, which was successfully implemented, takes a few seconds. To cite this article: M. Goldman, H. Jóhannesson, C. R. Physique 6 (2005).

The full text of this article is available in PDF format.

Mots-clés : Polarisation induite, Para hydrogène, Impulsions de radiofréquence, IRM

Keywords : Induced polarization, Para-hydrogen, Rf pulses, MRI


1  Consultant to GE Healthcare Bio-Sciences, Malmö, Sweden.


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