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Comptes Rendus Physique
Volume 5, n° 5
pages 589-596 (juin 2004)
Doi : 10.1016/j.crhy.2004.02.010
Biopuces pour le traitement de cellules vivantes : micromanipulation des cellules par voie électrique ou microfluidique
Parallel cell biochips: cell placement using dielectrophoresis or microfluidic effects

Bruno  Le Pioufle a ,  Marie  Frénéa a ,  Agnès  Tixier b
aBIOMIS/SATIE CNRS UMR 8029, ENS Cachan, campus de Ker-Lann, 35170 Bruz, France 
bLIMMS CNRS université de Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo, 153-8505, Japon 

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Après un bref état de l'art sur la recherche dans le domaine des biopuces cellulaire et des méthodes classiquement employées pour le placement et la caractérisation des cellules sur puce, nous présentons nos travaux sur la manipulation hautement parallélisée de cellules sur puce, par voie électrique ou microfluidique. Les applications envisagées des microdispositifs présentés concernent le transfert de gène, le criblage pharmacologique ou le tri cellulaire. Pour citer cet article : B. Le Pioufle et al., C. R. Physique 5 (2004).

Mots clés  : biopuce ; microfluidique ; diélectrophorèse ; cellule ; microsystème.

Abstract

After a brief overview of the state of the art in the domain of cell biochips, and more particularly, the usual methods for cell placement and characterization on a chip, our research on highly parallelized cell placement on a chip is presented. Single cell arraying methods, using dielectrophoresis effects, or microfluidic effects produced by bulk micromachined sub-micrometric capillaries are compared. Target applications of such cell biochips cover the domain of gene transfer on a large population of cells, parallelized cell sorting, or drug high-throughput screening on living cells. To cite this article: B. Le Pioufle et al., C. R. Physique 5 (2004).

Mots clés  : biochip ; microfluidic ; dielectrophoresis ; cell ; microsystems.




© 2004  Académie des sciences@@#104156@@

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