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Comptes Rendus Physique
Volume 3, n° 3
pages 391-396 (avril 2002)
Doi : S1631-0705(02)01315-4
Received : 24 October 2001 ; 
Voltage addressable nanomemories in DNA?
Nanomémoires adressables en ADN ?
 

Hervé Isambert
Laboratoire de dynamique des fluides complexes, Institut de physique, 3, rue de l'Université, 67000 Strasbourg, France 

Note presented by Pierre-Gilles de Gennes

Abstract

Short single-stranded DNA (or RNA) molecules can be designed to have several long lived (> hours) secondary structures. In principle, such molecules could be used as nanomemories if they could be easily induced to switch between trapped states. We propose here that the necessary work required to drive the molecule into one particular trapped state can be provided by its own synthesis . Following this idea, we argue that a low voltage (<1 V) may induce a bistable DNA molecule to switch structure at will, by forcing it to thread through a nanopore and refold alternatively from either of its ends. To cite this article: H. Isambert, C. R. Physique 3 (2002) 391-396.

The full text of this article is available in PDF format.
Résumé

Il est possible de concevoir des courtes séquences d'ADN simple-brin présentant plusieurs structures secondaires stables (> heures). En principe, de telles molécules pourraient être utilisées comme des nanomémoires si elles pouvaient être facilement passées d'un état piégé à un autre. Nous proposons ici que le travail nécessaire pour placer la molécule dans un état piégé particulier peut être fourni par sa propre synthèse. Prolongeant cette idée, nous montrons qu'une faible tension (<1 V) pourrait induire le basculement structural d'une molécule bistable à volonté, en la forçant à passer au travers d'un nanopore et à se replier alternativement ensuite à partir de l'une ou l'autre extrémité. Pour citer cet article : H. Isambert, C. R. Physique 3 (2002) 391-396.

The full text of this article is available in PDF format.

Keywords : nanomemory, nanopore, DNA synthesis

Mots-clé : nanomémoire, nanopore, synthèse de l'ADN




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